Methyldopa and propranolol or practolol in moderate hypertension.
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منابع مشابه
Methyldopa and propranolol or practolol in moderate hypertension.
The effect of a low dose of methyldopa combined with (a) a non-selective and (b) a selective beta-adrenoceptor antagonist was studied in a double-blind crossover trial in 24 carefully selected patients with moderate hypertension (mean initial lying blood pressure 189/117 mm Hg). Each patient received methyldopa 750 mg/day, propranolol 240 mg/day, practolol 600 mg/day, methyldopa 750 mg/day comb...
متن کاملA within-patient comparison of bethanidine, methyldopa and propranolol in the treatment of hypertension.
1. A within-patient comparison showed that bethanidine, methyldopa and propranolol produced similar control of the blood pressure. 2. Unlike bethanidine, propranolol did not produce postural and exercise hypotension; methyldopa was intermediate in effect. 3. Overall side effects were of a similar incidence though there were differences in incidence of particular side effects.
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Plasma concentrations of propranolol and practolol were measured in patients with coeliac disease and normal subjects. The mean plasma propranolol concentration in the coeliac patients was higher throughout the period of study, the differences being significant at one, six, and eight hours. The plasma concentration profile of practolol in the coeliacs followed a similar pattern but lagged behin...
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In a comparative trial practolol was found to be quite superior to propranolol in the treatment of spontaneous angina pectoris. Propranolol did not reduce the number of anginal attacks in the 24 hours, as evaluated through the patients' charting and continuous electrocardiographic recording, and induced exaggerated bradycardia as well as clinical and hemodynamic signs of poor cardiac performanc...
متن کاملPropranolol in hypertension.
Methods Twenty-five hypertensive male patients aged between 47 and 67 years (mean 54.6) attending the long term anticoagulant and hypertensive clinic at the County and Clayton Hospital in Wakefield were included in the trial. One patient withdrew because of side-effects. Eleven patients (Group 1) suffered from angina of effort, with or without myocardial infarction and were receiving glyceryl t...
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ژورنال
عنوان ژورنال: BMJ
سال: 1976
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.6028.137